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Respiratory depression is observed at higher doses. Sleep time: 10 ... High dosage may induce respiratory depression or muscular stiffness ... Methoxyflurane.

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Effects of high dose fentanyl anaesthesia on the established metabolic and .... of enflurane, isoflurane, halotane, methoxyflurane, and nitrous oxide in mice.

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aminopyrine metabolites by high-performance liquid chromatography. ... Lipka J.J., Waskell L.A. Methoxyflurane acts at the substrate binding site of cytochrome  ...

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1 feb. 2011 ... determined not only by the high incidence, but also etiology of the disease .... the penthrox' potential of use for pain relief in inter- nal medicine.

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Des distinctive properties are high saturated vapor pressure, super short ..... of enflurane, isoflurane, halotane, methoxyflurane, and nitrous oxide in mice. Anesth ...

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The high blood fluoride levels interfere with both the generation of maximally concentrated urine and tubular free water reabsorption.

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Renal: Methoxyflurane yields highest concentration of fluoride (F) which can damage the tubules and can cause vasopressin resistant high output (polyuric) renal failure.

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Methoxyflurane, formerly marketed as Penthrane, is a halogenated ether that was in clinical use as a volatile inhalational anesthetic from its introduction in 1960 until the late 1970s. It was first synthesized in the late 1940s by William T. Miller and his team of chemists following their involvement in the...

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Postpartum — High concentrations of inhalation anesthetics administered during prolonged delivery may increase the risk of neonatal depression. Methoxyflurane: Inorganic fluoride produced by...

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Methoxyflurane has a very high lipid solubility (oil:gas partition coefficient of around 950), which gives it very slow pharmacokinetics (induction and emergence characteristics)...

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The blood:gas partition coefficient for methoxyflurane is high, so induction, recovery and rate of change of anesthetic depth are slowed.

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Methoxyflurane has a very high lipid solubility (oil:gas partition coefficient of around 950), which gives it very slow pharmacokinetics (induction and emergence characteristics)...

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This was despite using high flow (liters/minute) of nitrous oxide and oxygen, and with the vaporizers delivering the maximum possible concentration of methoxyflurane.[18].

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